School of Dental Medicine - University at Buffalo

Gill, Steven Ph.D. Associate Professor, Department of Oral Biology

Address:

304a Foster Hall

Buffalo, NY 14214

(716)829-6001

srgill@buffalo.edu

Research Profile

Dr. Gill’s laboratory uses genomics and bioinformatics approaches to study bacterial pathogens, oral bacteria and commensal bacteria that reside in the human host. Current efforts are directed at: 1) genomic examination of virulence factors and clinical outcome of the bacterial pathogen, Staphylococcus aureus, 2) identification of factors in the oral bacteria, Streptococcus sp., which cause infective endocarditis, 3) metagenomic examination of the bacterial community that resides in the human oral cavity and 4) development of new genomics tools.

Representative Publications Search Publications in MEDLINE

Mongodin, E., Finan, J., Climo, M.W., Rosato, A., Gill, S.R. and Archer, G.L. (2003) Transcriptional analysis of clinical Staphylococcus aureus isolates resistant to vancomycin. J. Bacteriol. 185:4638-4643.
Weichhart, T., Horky, M., Sollner, J., Gangl, S., Henics, T., Nagy, E., Meinke, A., Von Gabain, A., Fraser, C.M., Gill, S.R., Hafner, M., and Von Ahsen, U. (2003) Functional selection of vaccine candidate peptides from Staphylococcus aureus whole-gnome expression libraries in vitro. Infect. Immun. 71:4633-4641.
Henics, T., Winkler, B., Pfeifer, U., Gill, S.R., Buschle, M., von Gabain, A. and Meinke, A. (2003) Small-fragment genomic libraries for the display of putative epitopes from clinically significant pathogens. Biotechniques 35:196-202.
Weigel, L.M., Clewell, D.B., Gill, S.R., Clark, N.C., McDougal, L.K., Flannagan, S.E., Kolonay, J.F., Shetty, J., Killgore, G.E., and Tenover, F.C. (2003) Molecular analysis of a clinical isolate of Staphylococcus aureus with high-level resistance to vancomycin. Science 302:1569-1571
Nguyen, T.N., Ejaz, A.D., Brancieri, M.A., Mikula, A.M., Nelson, K.E., Gill, S.R. and Noll, K.E. (2004) Whole-genome expression profiling of Thermotoga maritima in response to growth on sugars in a chemostat. J. Bacteriol. 186:4824-4828.
Nelson, K.E., Fouts, D.E., Mongodin, E.F., Ravel, J., DeBoy, R.T., Kolonay, J.F., Rasko, D.A., Angiuoli, S.V., Gill, S.R., Paulsen, I.T., Peterson, J., White, O., Nelson, W.C., Nierman, W., Beanan, M.J., Brinkac, L.M., Daugherty, S.C., Dodson, R.J., Durkin, A.S., Madupu, R., Haft, D.H., Selengut, J., Van Aken, S., Khouri, H., Fedorova, N., Forberger, H., Tran, B., Kathariou, S., Wonderling, L.D., Uhlich, G.A., Bayles, D.O., Luchansky, J.B. and Fraser, C.M. (2004) Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species. Nucleic Acids Res. 32:2386-2395.
Gill, S.R., Fouts, D.E., Archer, G.L., Mongodin, E.F., DeBoy, R.T., Ravel, J., Paulsen, I.T., Kolonay, J.F., Brinkac, L., Beanan, M., Dodson, R.J., Daugherty, S.C., Madupu, R., Angiuoli, S.V., Durkin, A.S., Haft, D.H., Vamathevan, J., Khouri, H., Utterback, T., Lee, C., Dimitrov, G., Jiang, L., Qin, H., Weidman, J., Tran, K., Kang, K., Hance, I.R., Nelson, K.E., and Fraser, C.M. (2005) Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin resistant Staphylococcus aureus and a biofilm producing methicillin resistant Staphylococcus epidermidis. J. Bacteriol. 187:2426-2438.
Eckburg, P.B., Bik, E.M., Bernstein, C.N., Sargent, M., Dethlefsen, L., Purdom, E., Gill, S.R., Nelson, K.E. and Relman, D.A. (2005) Diversity of the human intestinal microflora. Science 308:1635-1638.
Mongodin, E.F., Hance, I.R., DeBoy, R.T., Gill, S.R., Daugherty, S. Huber, R., Fraser, C.M., Stetter, K. and Nelson, K.E. (2005) Gene transfer and genome plasticity in Thermotoga maritima, a model hyperthermophilic species. J. Bacteriol. 187:4935-4944.
Bik, E.M., Eckburg, P.B., Gill, S.R., Nelson, K.E., Purdom, E.A., Francois, F., Perez-Perez, G., Blaser, M.J., and Relman, D.A. (2006) Molecular analysis of the bacterial microbiota in the human stomach. Proc. Natl. Acad. Sci. USA 103:732-737.
Gatlin, C.L., Pieper, R., Huang, S.T., Mongodin, E., Gebregeorgis, E., Parmar, P.P., Clark, D.J., Alami, H., Papazisi, L., Fleischmann, R.D., Gill, S.R., and Peterson, S.N. (2006) Proteomic profiling of cell envelope-associated proteins from Staphylococcus aureus. Proteomics 6:1530-1536.
Binh An Diep, Gill, S.R., Chang, R.F., Phan, T.H., Chen, J., Davidson, M.G., Lin, F., Lin, J., Carleton, H.A., Mongodin, E.F., Sensabaugh, G.F., Crim, D. and Perdreau-Remington, F. (2006) The Complete Genome Sequence of USA300, A Multidrug-Resistant Hypervirulent Community-acquired Methicillin-Resistant Staphylococcus aureus Strain. Lancet 367:731-739.
Fouts, D.E., Rasko, D.A., Cer, R.Z., Jiang, L., Fedorova, N.B., Shvartsbeyn, A., Vamathevan, J.J., Tallon, L., Althoff, R., Arbogast, T.S., Fadrosh, D.W., Read, T.D., and Gill, S.R. (2006) Sequencing Bacillus anthracis typing phages Gamma and Cherry reveals a common ancestry. J. Bacteriol. 188:3402-3408.
Gill, S.R., Pop, M., R.T. DeBoy, Eckburg, P.B., Turnbaugh, P., Samuel, B.S., Gordon, J.I., Relman, D.A., Fraser, C.M. and Nelson, K.E. (2006) Metagenomic analysis of the human colonic microbiome. Science 312:1355-1359